InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NOTCH3

Summary

InnateDB Gene

IDBG-642521.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOTCH3

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000043971

Encoded Proteins

IDBP-695022

notch 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074181:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:8930803-8970307

Strand

Forward strand

Band

Transcripts

ENSBTAT00000060960

ENSBTAP00000053357

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030900	forebrain development
GO:0045596	negative regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048663	neuron fate commitment
GO:0050793	regulation of developmental process
GO:0072104	glomerular capillary formation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex