Version 5.4
Bos taurus Protein: TGM2
Summary
InnateDB Protein IDBP-695048.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM2
Protein Name protein-glutamine gamma-glutamyltransferase 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021569
InnateDB Gene IDBG-642580 (TGM2)
Protein Structure
UniProt Annotation
Function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Subcellular Localization
Disease Associations
Tissue Specificity Highest levels are detected in the lung. Lower levels are found in the liver, spleen and heart, but not in the brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0018149 peptide cross-linking
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065 positive regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0045785 positive regulation of cell adhesion
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060662 salivary gland cavitation
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001102 Transglutaminase, N-terminal
IPR002931 Transglutaminase-like
IPR008958 Transglutaminase, C-terminal
IPR014756 Immunoglobulin E-set
PFAM PF00868
PF01841
PF00927
PRINTS
PIRSF
SMART SM00460
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51176
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281528
UniGene Bt.5401
RefSeq NP_803473
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103290 X60686
GenPept AAI03291 CAA43097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca