Version 5.4
Bos taurus Protein: BAIAP2
Summary
InnateDB Protein IDBP-695058.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAIAP2
Protein Name Brain-specific angiogenesis inhibitor 1-associated protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025350
InnateDB Gene IDBG-642589 (BAIAP2)
Protein Structure
UniProt Annotation
Function Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0017124 SH3 domain binding
GO:0070064 proline-rich region binding
Biological Process
GO:0007009 plasma membrane organization
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0009617 response to bacterium
GO:0032956 regulation of actin cytoskeleton organization
GO:0046847 filopodium assembly
GO:0051017 actin filament bundle assembly
GO:0051764 actin crosslink formation
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030175 filopodium
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013606 IRSp53/MIM homology domain (IMD)
PFAM PF00018
PF14604
PF07653
PF08397
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EAD0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507837
UniGene Bt.17140
RefSeq NP_001017937
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT020639
GenPept AAX08656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca