InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BAIAP2

Summary

InnateDB Gene

IDBG-642589.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAIAP2

Gene Name

Brain-specific angiogenesis inhibitor 1-associated protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019044

Encoded Proteins

IDBP-695058

Brain-specific angiogenesis inhibitor 1-associated protein 2

IDBP-695059

Brain-specific angiogenesis inhibitor 1-associated protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175866:
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:52198617-52263294

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025350	ENSBTAP00000025350
ENSBTAT00000042599	ENSBTAP00000040235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0008360	regulation of cell shape
GO:0009617	response to bacterium
GO:0016358	dendrite development
GO:0032956	regulation of actin cytoskeleton organization
GO:0046847	filopodium assembly
GO:0048167	regulation of synaptic plasticity
GO:0051017	actin filament bundle assembly
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030175	filopodium
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome