Version 5.4
Bos taurus Protein: CHEK1
Summary
InnateDB Protein IDBP-695182.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHEK1
Protein Name serine/threonine-protein kinase Chk1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023380
InnateDB Gene IDBG-642697 (CHEK1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035402 histone kinase activity (H3-T11 specific)
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0010468 regulation of gene expression
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0018107 peptidyl-threonine phosphorylation
GO:0031572 G2 DNA damage checkpoint
GO:0035407 histone H3-T11 phosphorylation
GO:0042127 regulation of cell proliferation
GO:0045839 negative regulation of mitosis
GO:0046602 regulation of mitotic centrosome separation
GO:0048096 chromatin-mediated maintenance of transcription
GO:0071260 cellular response to mechanical stimulus
GO:2000615 regulation of histone H3-K9 acetylation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000794 condensed nuclear chromosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005813 centrosome
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D7V1
UniProt Splice Variant
Entrez Gene 513678
UniGene Bt.10253
RefSeq NP_001091492
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140691 DAAA02063091 DAAA02063092
GenPept AAI40692

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca