InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHEK1

Summary

InnateDB Gene

IDBG-642697.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHEK1

Gene Name

serine/threonine-protein kinase Chk1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017582

Encoded Proteins

IDBP-695182

serine/threonine-protein kinase Chk1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149554:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:29402369-29420344

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023380

ENSBTAP00000023380

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035402	histone kinase activity (H3-T11 specific)

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000086	G2/M transition of mitotic cell cycle
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0010468	regulation of gene expression
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0018107	peptidyl-threonine phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0035407	histone H3-T11 phosphorylation
GO:0042127	regulation of cell proliferation
GO:0045839	negative regulation of mitosis
GO:0046602	regulation of mitotic centrosome separation
GO:0048096	chromatin-mediated maintenance of transcription
GO:0071260	cellular response to mechanical stimulus
GO:2000615	regulation of histone H3-K9 acetylation

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000785	chromatin
GO:0000794	condensed nuclear chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005657	replication fork
GO:0005813	centrosome
GO:0043231	intracellular membrane-bounded organelle