InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: STAT1

Summary

InnateDB Protein

IDBP-695242.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT1

Protein Name

signal transducer and activator of transcription 1-alpha/beta

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053390

InnateDB Gene

IDBG-642654 (STAT1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0009617	response to bacterium
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034240	negative regulation of macrophage fusion
GO:0035458	cellular response to interferon-beta
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061326	renal tubule development

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil
IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864
PF12162

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BPP7

UniProt Splice Variant

Entrez Gene

515988

UniGene

Bt.33292

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02005373 DAAA02005374

GenPept