Version 5.4
Bos taurus Protein: STAT1
Summary
InnateDB Protein IDBP-695255.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT1
Protein Name signal transducer and activator of transcription 1-alpha/beta
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010351
InnateDB Gene IDBG-642654 (STAT1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0016525 negative regulation of angiogenesis
GO:0032869 cellular response to insulin stimulus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043434 response to peptide hormone
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil
IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
PFAM PF00017
PF14633
PF02865
PF01017
PF02864
PF12162
PRINTS PR00401
PIRSF
SMART SM00252
SM00964
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B0JYL6
UniProt Splice Variant
Entrez Gene 515988
UniGene Bt.33292
RefSeq NP_001071368
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151378 DAAA02005373 DAAA02005374
GenPept AAI51379

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca