Version 5.4
Bos taurus Protein: YWHAB
Summary
InnateDB Protein IDBP-695323.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAB
Protein Name 14-3-3 protein beta/alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022411
InnateDB Gene IDBG-642828 (YWHAB)
Protein Structure
UniProt Annotation
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Melanosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 227 interaction(s) predicted by orthology.
Predicted by orthology
Total 227 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0042826 histone deacetylase binding
GO:0050815 phosphoserine binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006605 protein targeting
GO:0035308 negative regulation of protein dephosphorylation
GO:0043085 positive regulation of catalytic activity
GO:0051220 cytoplasmic sequestering of protein
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042470 melanosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000308 14-3-3 protein
IPR023410 14-3-3 domain
PFAM PF00244
PRINTS PR00305
PIRSF PIRSF000868
SMART SM00101
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P68250
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 286863
UniGene Bt.66524
RefSeq NP_777219
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF043736 BC120112
GenPept AAC02090 AAI20113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca