Version 5.4
| Bos taurus Gene: YWHAB | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||
| InnateDB Gene | IDBG-642828.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | YWHAB | ||||||||||||||
| Gene Name | 14-3-3 protein beta/alpha 14-3-3 protein beta/alpha, N-terminally processed | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Gene | ENSBTAG00000016846 | ||||||||||||||
| Encoded Proteins |
14-3-3 protein beta/alpha
|
||||||||||||||
| Protein Structure |
|
||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166913:
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||
| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 13:74018886-74040819 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | |||||||||||||||
| Transcripts |
|
||||||||||||||
| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 227 interaction(s) predicted by orthology.
|
||||||||||||||
| Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
| Biological Process |
|
||||||||||||||
| Cellular Component |
|
||||||||||||||
| Orthologs | |||||||||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||
| Pathways | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
DAP12 interactions pathway
Insulin receptor signalling cascade pathway
Signaling by EGFR pathway
ARMS-mediated activation pathway
Signalling to ERKs pathway
GRB2 events in ERBB2 signaling pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
IRS-related events triggered by IGF1R pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
NCAM signaling for neurite out-growth pathway
Signaling by GPCR pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
Signaling by PDGF pathway
Signaling by Leptin pathway
Signaling by ERBB4 pathway
SHC-mediated signalling pathway
SHC1 events in ERBB2 signaling pathway
Activation of BH3-only proteins pathway
Signaling by FGFR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Prolonged ERK activation events pathway
IRS-related events pathway
VEGFA-VEGFR2 Pathway pathway
SHC1 events in EGFR signaling pathway
Translocation of GLUT4 to the plasma membrane pathway
Gene Expression pathway
Immune System pathway
IRS-mediated signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
VEGFR2 mediated cell proliferation pathway
SHC-related events pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by Insulin receptor pathway
Signaling by EGFR in Cancer pathway
Signalling to RAS pathway
Tristetraprolin (TTP) destabilizes mRNA pathway
RAF/MAP kinase cascade pathway
SHC1 events in ERBB4 signaling pathway
Axon guidance pathway
Signalling to p38 via RIT and RIN pathway
SHC-related events triggered by IGF1R pathway
NGF signalling via TRKA from the plasma membrane pathway
Intrinsic Pathway for Apoptosis pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
Signaling by VEGF pathway
MEK activation pathway
Adaptive Immune System pathway
GRB2 events in EGFR signaling pathway
Activation of BAD and translocation to mitochondria pathway
Downstream signal transduction pathway
RAF phosphorylates MEK pathway
Rap1 signalling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
FCERI mediated MAPK activation pathway
Frs2-mediated activation pathway
FRS2-mediated cascade pathway
Signaling by Interleukins pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Hippo pathway
Apoptosis pathway
RAF activation pathway
Developmental Biology pathway
Membrane Trafficking pathway
|
||||||||||||||
| KEGG | |||||||||||||||
| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
Wnt pathway
TNFalpha pathway
IL3 pathway
|
||||||||||||||
| REACTOME |
RAF activation pathway
RAF phosphorylates MEK pathway
MEK activation pathway
DAP12 signaling pathway
DAP12 interactions pathway
Rap1 signalling pathway
Interleukin-2 signaling pathway
Frs2-mediated activation pathway
ARMS-mediated activation pathway
Signalling to p38 via RIT and RIN pathway
Signalling to RAS pathway
SOS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
GRB2 events in EGFR signaling pathway
Signaling by EGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
SHC-mediated signalling pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
FRS2-mediated cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Signaling by Hippo pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
Tristetraprolin (TTP) destabilizes mRNA pathway
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
NCAM signaling for neurite out-growth pathway
Signaling by FGFR in disease pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Prolonged ERK activation events pathway
Intrinsic Pathway for Apoptosis pathway
Gene Expression pathway
Disease pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Membrane Trafficking pathway
Innate Immune System pathway
Apoptosis pathway
Signaling by ERBB2 pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
Membrane Trafficking pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Tristetraprolin (TTP) destabilizes mRNA pathway
RAF phosphorylates MEK pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
VEGFR2 mediated cell proliferation pathway
Immune System pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
Activation of BAD and translocation to mitochondria pathway
SHC1 events in EGFR signaling pathway
RAF activation pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Rap1 signalling pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Signaling by Hippo pathway
Fc epsilon receptor (FCERI) signaling pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Signalling by NGF pathway
Gene Expression pathway
Activation of BH3-only proteins pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SOS-mediated signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ARMS-mediated activation pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
FCERI mediated MAPK activation pathway
MEK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
Translocation of GLUT4 to the plasma membrane pathway
DAP12 interactions pathway
DAP12 signaling pathway
Intrinsic Pathway for Apoptosis pathway
|
||||||||||||||
| KEGG |
Cell cycle pathway
Oocyte meiosis pathway
Cell cycle pathway
Oocyte meiosis pathway
|
||||||||||||||
| INOH |
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
|
||||||||||||||
| PID NCI |
Signaling events mediated by HDAC Class II
ATM pathway
ATR signaling pathway
|
||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | P68250 | ||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | 286863 | ||||||||||||||
| UniGene | Bt.104388 Bt.5535 Bt.66524 | ||||||||||||||
| RefSeq | NM_174794 | ||||||||||||||
| HUGO | |||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | AF043736 BC120112 | ||||||||||||||
| GenPept | AAC02090 AAI20113 | ||||||||||||||
| RNA Seq Atlas | 286863 | ||||||||||||||