InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CACNA1A

Summary

InnateDB Protein

IDBP-695325.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1A

Protein Name

voltage-dependent P/Q-type calcium channel subunit alpha-1A

Synonyms

CAV2.1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019752

InnateDB Gene

IDBG-642817 (CACNA1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0019905	syntaxin binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006006	glucose metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007274	neuromuscular synaptic transmission
GO:0007416	synapse assembly
GO:0007628	adult walking behavior
GO:0008219	cell death
GO:0014051	gamma-aminobutyric acid secretion
GO:0014056	regulation of acetylcholine secretion
GO:0016049	cell growth
GO:0017156	calcium ion-dependent exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0019226	transmission of nerve impulse
GO:0021522	spinal cord motor neuron differentiation
GO:0021590	cerebellum maturation
GO:0021679	cerebellar molecular layer development
GO:0021680	cerebellar Purkinje cell layer development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021750	vestibular nucleus development
GO:0021953	central nervous system neuron differentiation
GO:0030644	cellular chloride ion homeostasis
GO:0032353	negative regulation of hormone biosynthetic process
GO:0034765	regulation of ion transmembrane transport
GO:0035249	synaptic transmission, glutamatergic
GO:0042133	neurotransmitter metabolic process
GO:0042391	regulation of membrane potential
GO:0042445	hormone metabolic process
GO:0043113	receptor clustering
GO:0043524	negative regulation of neuron apoptotic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0048791	calcium ion-dependent exocytosis of neurotransmitter
GO:0048813	dendrite morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050877	neurological system process
GO:0050883	musculoskeletal movement, spinal reflex action
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process
GO:0051899	membrane depolarization
GO:0055085	transmembrane transport
GO:0060024	rhythmic synaptic transmission
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0042995	cell projection
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005448 Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01632

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt