Version 5.4
Bos taurus Protein: CALR
Summary
InnateDB Protein IDBP-695391.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALR
Protein Name calreticulin precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020111
InnateDB Gene IDBG-642890 (CALR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003729 mRNA binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
GO:0050681 androgen receptor binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002502 peptide antigen assembly with MHC class I protein complex
GO:0006457 protein folding
GO:0006611 protein export from nucleus
GO:0007050 cell cycle arrest
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030866 cortical actin cytoskeleton organization
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0034504 protein localization to nucleus
GO:0040020 regulation of meiosis
GO:0045665 negative regulation of neuron differentiation
GO:0045740 positive regulation of DNA replication
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0050766 positive regulation of phagocytosis
GO:0050821 protein stabilization
GO:0090398 cellular senescence
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:2000510 positive regulation of dendritic cell chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005844 polysome
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0042824 MHC class I peptide loading complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001580 Calreticulin/calnexin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009169 Calreticulin
PFAM PF00262
PRINTS PR00626
PIRSF PIRSF002356
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D7J6
UniProt Splice Variant
Entrez Gene 281036
UniGene Bt.30105
RefSeq NP_776425
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140582 DAAA02019382
GenPept AAI40583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca