Version 5.4
Bos taurus Gene: CALR
Summary
InnateDB Gene IDBG-642890.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALR
Gene Name calreticulin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015114
Encoded Proteins
IDBP-695391
calreticulin precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179218:
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13731958-13735788
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020111 ENSBTAP00000020111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003729 mRNA binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0031625 ubiquitin protein ligase binding
GO:0044822 poly(A) RNA binding
GO:0050681 androgen receptor binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002502 peptide antigen assembly with MHC class I protein complex
GO:0006457 protein folding
GO:0006611 protein export from nucleus
GO:0007050 cell cycle arrest
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030866 cortical actin cytoskeleton organization
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0034504 protein localization to nucleus
GO:0040020 regulation of meiosis
GO:0045665 negative regulation of neuron differentiation
GO:0045740 positive regulation of DNA replication
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0050766 positive regulation of phagocytosis
GO:0050821 protein stabilization
GO:0090398 cellular senescence
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:2000510 positive regulation of dendritic cell chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005844 polysome
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0042824 MHC class I peptide loading complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000179218
View Gene Order
ENSMUSG00000003814
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_23
TSH pathway
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_111178
ER-Phagosome pathway pathway
REACT_18423
ATF6-alpha activates chaperone genes pathway
REACT_18348
ATF6-alpha activates chaperones pathway
REACT_23810
Calnexin/calreticulin cycle pathway
REACT_23878
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_6277
Assembly of Viral Components at the Budding Site pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_6167
Influenza Infection pathway
REACT_22161
Post-translational protein modification pathway
REACT_163813
Scavenging by Class F Receptors pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_6270
Virus Assembly and Release pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_6145
Influenza Life Cycle pathway
REACT_116125
Disease pathway
REACT_32838
ATF6-alpha activates chaperone genes pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_236283
Post-translational protein modification pathway
REACT_199105
ER-Phagosome pathway pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_231897
ATF6-alpha activates chaperones pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_229531
Adaptive Immune System pathway
REACT_196603
Scavenging by Class F Receptors pathway
REACT_198618
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
REACT_198616
Calnexin/calreticulin cycle pathway
REACT_246972
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
KEGG
hsa04612
Antigen processing and presentation pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04145
Phagosome pathway
mmu04612
Antigen processing and presentation pathway
mmu04145
Phagosome pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A5D7J6
UniProt Splice Variant
Entrez Gene 281036
UniGene Bt.30105
RefSeq NM_174000
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140582 DAAA02019382
GenPept AAI40583
RNA Seq Atlas 281036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca