InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.89909

Summary

InnateDB Protein

IDBP-695445.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.89909

Protein Name

60 kDa heat shock protein, mitochondrial

Synonyms

HSP60;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000055431

InnateDB Gene

IDBG-642936 (BT.89909)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001530	lipopolysaccharide binding
GO:0002039	p53 binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0002368	B cell cytokine production
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002842	positive regulation of T cell mediated immune response to tumor cell
GO:0006457	protein folding
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986	response to unfolded protein
GO:0032727	positive regulation of interferon-alpha production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0042026	protein refolding
GO:0042100	B cell proliferation
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0043032	positive regulation of macrophage activation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0048291	isotype switching to IgG isotypes
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016020	membrane
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135	coated vesicle
GO:0030141	secretory granule
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0046696	lipopolysaccharide receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409 GroEL-like apical domain

PFAM

PF00118

PRINTS

PR00298
PR00304

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite