InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.89909

Summary

InnateDB Gene

IDBG-642936.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.89909

Gene Name

60 kDa heat shock protein, mitochondrial

Synonyms

HSP60

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012586

Encoded Proteins

IDBP-695445

60 kDa heat shock protein, mitochondrial

IDBP-695448

60 kDa heat shock protein, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18575269

[Homo sapiens] HSPD1 is part of the heat shock family of proteins that have many roles in inflammation and regulation of the immune system.

PMID 21145789

[Homo sapiens] HSPD1 plays a dual role as an immune modulator and a biomarker, and is a target to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease.

PMID 21775438

[Homo sapiens] HSPD1 and TLR4 mediate myocardial ischemia-activated innate immune signalling, which plays an important role in mediating apoptosis and inflammation during ischemia/reperfusion (I/R). (Demonstrated in murine model)

PMID 21145789

[Mus musculus] Hspd1 plays a dual role as an immune modulator and a biomarker, and is a target to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease.

PMID 21775438

[Mus musculus] Hspd1 and Tlr4 mediate myocardial ischemia-activated innate immune signalling, which plays an important role in mediating apoptosis and inflammation during ischemia/reperfusion (I/R).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144381:
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:86438979-86449372

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064253	ENSBTAP00000055431
ENSBTAT00000016708	ENSBTAP00000016708

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Predicted by orthology
Total	115 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001530	lipopolysaccharide binding
GO:0002039	p53 binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0002368	B cell cytokine production
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002842	positive regulation of T cell mediated immune response to tumor cell
GO:0006457	protein folding
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986	response to unfolded protein
GO:0032727	positive regulation of interferon-alpha production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0042026	protein refolding
GO:0042100	B cell proliferation
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0043032	positive regulation of macrophage activation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0048291	isotype switching to IgG isotypes
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016020	membrane
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135	coated vesicle
GO:0030141	secretory granule
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0046696	lipopolysaccharide receptor complex
GO:0070062	extracellular vesicular exosome