InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CTSA

Summary

InnateDB Protein

IDBP-695483.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSA

Protein Name

Lysosomal protective proteinLysosomal protective protein 32 kDa chainLysosomal protective protein 20 kDa chain

Synonyms

PPCA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000039003

InnateDB Gene

IDBG-642969 (CTSA)

Protein Structure

UniProt Annotation

Function

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004185	serine-type carboxypeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001563 Peptidase S10, serine carboxypeptidase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00450

PRINTS

PR00724

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3MI05

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

518169

UniGene

Bt.21410

RefSeq

NP_001030403

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC104495

GenPept

AAI04496