InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CTSA

Summary

InnateDB Gene

IDBG-642969.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSA

Gene Name

Lysosomal protective protein Lysosomal protective protein 32 kDa chain Lysosomal protective protein 20 kDa chain

Synonyms

PPCA

Species

Bos taurus

Ensembl Gene

ENSBTAG00000027337

Encoded Proteins

IDBP-695483

Lysosomal protective proteinLysosomal protective protein 32 kDa chainLysosomal protective protein 20 kDa chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064601:
This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:75368317-75374637

Strand

Forward strand

Band

Transcripts

ENSBTAT00000039203

ENSBTAP00000039003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004185	serine-type carboxypeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome