Version 5.4
Bos taurus Protein: AFP
Summary
InnateDB Protein IDBP-695513.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFP
Protein Name Alpha-fetoprotein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022772
InnateDB Gene IDBG-642999 (AFP)
Protein Structure
UniProt Annotation
Function Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000255PROSITE- ProRule:PRU00769}.
Disease Associations
Tissue Specificity Plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0001542 ovulation from ovarian follicle
GO:0006810 transport
GO:0019953 sexual reproduction
GO:0042448 progesterone metabolic process
GO:0060395 SMAD protein signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000264 ALB/AFP/VDB
IPR001703 Alpha-fetoprotein
IPR014760 Serum albumin, N-terminal
IPR020858 Serum albumin-like
IPR021177 Serum albumin/Alpha-fetoprotein
PFAM PF00273
PRINTS PR00802
PR00803
PIRSF PIRSF002520
SMART SM00103
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZ57
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506011
UniGene Bt.97413
RefSeq NP_001029434
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103123
GenPept AAI03124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca