Version 5.4
Bos taurus Gene: AFP
Summary
InnateDB Gene IDBG-642999.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFP
Gene Name Alpha-fetoprotein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017131
Encoded Proteins
IDBP-695513
Alpha-fetoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081051:
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:90258976-90280522
Strand Forward strand
Band
Transcripts
ENSBTAT00000022772 ENSBTAP00000022772
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0001542 ovulation from ovarian follicle
GO:0006810 transport
GO:0019953 sexual reproduction
GO:0042448 progesterone metabolic process
GO:0060395 SMAD protein signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000081051
View Gene Order
ENSMUSG00000054932
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
p53downstreampathway
Direct p53 effectors
reg_gr_pathway
Glucocorticoid receptor regulatory network
p73pathway
p73 transcription factor network
Cross-References
SwissProt Q3SZ57
TrEMBL
UniProt Splice Variant
Entrez Gene 506011
UniGene Bt.32650 Bt.97413
RefSeq NM_001034262
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103123
GenPept AAI03124
RNA Seq Atlas 506011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca