Version 5.4
Bos taurus Protein: SPHK1
Summary
InnateDB Protein IDBP-695596.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPHK1
Protein Name sphingosine kinase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011212
InnateDB Gene IDBG-643068 (SPHK1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008481 sphinganine kinase activity
GO:0017050 D-erythro-sphingosine kinase activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0001568 blood vessel development
GO:0006670 sphingosine metabolic process
GO:0006954 inflammatory response
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420 brain development
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016310 phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031398 positive regulation of protein ubiquitination
GO:0032651 regulation of interleukin-1 beta production
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0045766 positive regulation of angiogenesis
GO:0045931 positive regulation of mitotic cell cycle
GO:0045987 positive regulation of smooth muscle contraction
GO:0048146 positive regulation of fibroblast proliferation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
PFAM PF00781
PRINTS
PIRSF
SMART SM00046
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MXZ6
UniProt Splice Variant
Entrez Gene 618605
UniGene
RefSeq XP_002696250
HUGO HGNC:11240
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049503
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca