InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPHK1

Summary

InnateDB Gene

IDBG-643068.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPHK1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008507

Encoded Proteins

IDBP-695596

sphingosine kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20634980

[Homo sapiens] SPHK1 is involved in toll-mediated human beta-defensin 2 (HBD-2) regulation in oral keratinocytes, which also involves the activation of PI3K, AKT, GSK3B (GSK-3beta) and ERK 1/2.

PMID 20661259

[Homo sapiens] SPHK1 activation, mediated by TLR4, is found to be critical for the redox-dependent activation of HIF-1alpha and ASK1, as well as for the prevention of LPS-induced activation of caspase 3 and the expression of pro-inflammatory cytokine interleukin-6.

PMID 26113114

[Homo sapiens] (S)-methyl 2-(hexanamide)-3-(4-hydroxyphenyl) propanoate (MHP) activates SPHK1, which also stimulates CAMP production and enhances epidermal antimicrobial defence.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176170:
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:55978951-55981068

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011212

ENSBTAP00000011212

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017050	D-erythro-sphingosine kinase activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0001568	blood vessel development
GO:0006670	sphingosine metabolic process
GO:0006954	inflammatory response
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0008152	metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0016310	phosphorylation
GO:0019722	calcium-mediated signaling
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0031398	positive regulation of protein ubiquitination
GO:0032651	regulation of interleukin-1 beta production
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045766	positive regulation of angiogenesis
GO:0045931	positive regulation of mitotic cell cycle
GO:0045987	positive regulation of smooth muscle contraction
GO:0048146	positive regulation of fibroblast proliferation
GO:0051092	positive regulation of NF-kappaB transcription factor activity