Version 5.4
Bos taurus Protein: ARFGEF2
Summary
InnateDB Protein IDBP-695675.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGEF2
Protein Name ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009376
InnateDB Gene IDBG-643137 (ARFGEF2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0034237 protein kinase A regulatory subunit binding
Biological Process
GO:0001881 receptor recycling
GO:0006893 Golgi to plasma membrane transport
GO:0007032 endosome organization
GO:0010256 endomembrane system organization
GO:0032012 regulation of ARF protein signal transduction
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0016020 membrane
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR015403 Domain of unknown function DUF1981, Sec7 associated
IPR016024 Armadillo-type fold
PFAM PF01369
PF09324
PRINTS
PIRSF
SMART SM00222
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BKI9
UniProt Splice Variant
Entrez Gene 539295
UniGene
RefSeq NP_001192581
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036826 DAAA02036827
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca