InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARFGEF2

Summary

InnateDB Gene

IDBG-643137.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARFGEF2

Gene Name

brefeldin A-inhibited guanine nucleotide-exchange protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007120

Encoded Proteins

IDBP-695675

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124198:
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:77822894-77903223

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009376

ENSBTAP00000009376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0034237	protein kinase A regulatory subunit binding

Biological Process

GO:0001881	receptor recycling
GO:0006893	Golgi to plasma membrane transport
GO:0007032	endosome organization
GO:0010256	endomembrane system organization
GO:0032012	regulation of ARF protein signal transduction
GO:0032760	positive regulation of tumor necrosis factor production
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity