Version 5.4
Bos taurus Protein: RASGEF1B
Summary
InnateDB Protein IDBP-695716.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGEF1B
Protein Name Ras-GEF domain-containing family member 1B
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042728
InnateDB Gene IDBG-643174 (RASGEF1B)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro). {ECO:0000250}.
Subcellular Localization Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Midbody {ECO:0000250}. Note=Localizes to midbody at telophase (By similarity). Localizes to midbody at telophase (By similarity). May shuttle between early and late endosomes. Does not colocalize with lysosomal markers (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain
PFAM PF00618
PF00617
PRINTS
PIRSF
SMART SM00229
SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4IFE4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506971
UniGene Bt.6800
RefSeq NP_001077118
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134542
GenPept AAI34543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca