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InnateDB Protein
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IDBP-695896.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ICT1
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Protein Name
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Peptidyl-tRNA hydrolase ICT1, mitochondrial
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Synonyms
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MRP-L58;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000004276
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InnateDB Gene
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IDBG-643343 (ICT1)
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Protein Structure
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| Function |
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Mitochondrion {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 229 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
229 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0003747
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translation release factor activity
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GO:0004045
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aminoacyl-tRNA hydrolase activity
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GO:0016150
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translation release factor activity, codon nonspecific
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GO:0016787
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hydrolase activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR000352
Peptide chain release factor class I/class II
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| PFAM |
PF00472
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q3T116
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
515465
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| UniGene |
Bt.49175
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| RefSeq |
NP_001029665
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC102162
BC134736
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| GenPept |
AAI02163
AAI34737
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Version 5.4