Version 5.4
Bos taurus Gene: ICT1
Summary
InnateDB Gene IDBG-643343.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICT1
Gene Name Peptidyl-tRNA hydrolase ICT1, mitochondrial
Synonyms MRP-L58
Species Bos taurus
Ensembl Gene ENSBTAG00000003303
Encoded Proteins
IDBP-695896
Peptidyl-tRNA hydrolase ICT1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167862:
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:57040855-57047924
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004276 ENSBTAP00000004276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 229 interaction(s) predicted by orthology.
Predicted by orthology
Total 229 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003747 translation release factor activity
GO:0004045 aminoacyl-tRNA hydrolase activity
GO:0016150 translation release factor activity, codon nonspecific
GO:0016787 hydrolase activity
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0070126 mitochondrial translational termination
Cellular Component
GO:0005739 mitochondrion
GO:0005762 mitochondrial large ribosomal subunit
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000167862
View Gene Order
ENSMUSG00000018858
View Gene Order
Pathways
NETPATH
REACTOME
REACT_270797
Mitochondrial translation initiation pathway
REACT_271447
Mitochondrial translation elongation pathway
REACT_270450
Mitochondrial translation pathway
REACT_270960
Mitochondrial translation termination pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267680
Mitochondrial translation initiation pathway
REACT_267602
Mitochondrial translation termination pathway
REACT_267677
Mitochondrial translation elongation pathway
REACT_268789
Mitochondrial translation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_270125
Mitochondrial translation elongation pathway
REACT_271096
Mitochondrial translation initiation pathway
REACT_270158
Mitochondrial translation termination pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3T116
TrEMBL
UniProt Splice Variant
Entrez Gene 515465
UniGene Bt.49175
RefSeq NM_001034493
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102162 BC134736
GenPept AAI02163 AAI34737
RNA Seq Atlas 515465

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca