InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TONSL

Summary

InnateDB Protein

IDBP-696081.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TONSL

Protein Name

Tonsoku-like protein

Synonyms

NFKBIL2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010191

InnateDB Gene

IDBG-643519 (TONSL)

Protein Structure

UniProt Annotation

Function

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0042393	histone binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0031297	replication fork processing

Cellular Component

GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0005737	cytoplasm
GO:0035101	FACT complex
GO:0042555	MCM complex
GO:0043596	nuclear replication fork

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR006553 Leucine-rich repeat, cysteine-containing subtype
IPR016024 Armadillo-type fold
IPR019734 Tetratricopeptide repeat
IPR020683 Ankyrin repeat-containing domain

PFAM