Version 5.4
Bos taurus Gene: TONSL
Summary
InnateDB Gene IDBG-643519.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TONSL
Gene Name Tonsoku-like protein
Synonyms NFKBIL2
Species Bos taurus
Ensembl Gene ENSBTAG00000007749
Encoded Proteins
IDBP-696081
Tonsoku-like protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160949:
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:1681494-1692498
Strand Forward strand
Band
Transcripts
ENSBTAT00000010191 ENSBTAP00000010191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0031297 replication fork processing
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
GO:0005737 cytoplasm
GO:0035101 FACT complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000160949
View Gene Order
ENSMUSG00000059323
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_198518
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.13716
RefSeq NM_001075188
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca