InnateDB Protein
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IDBP-696154.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HSF1
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Protein Name
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Heat shock factor protein 1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000027654
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InnateDB Gene
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IDBG-643592 (HSF1)
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Protein Structure
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Function |
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
53 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0001162
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RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
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GO:0003677
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DNA binding
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GO:0003682
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chromatin binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000232
Heat shock factor (HSF)-type, DNA-binding
IPR010542
Vertebrate heat shock transcription factor, C-terminal domain
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PFAM |
PF00447
PF06546
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PRINTS |
PR00056
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PIRSF |
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SMART |
SM00415
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TIGRFAMs |
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Modification |
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SwissProt |
Q08DJ8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q8MI48
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UniProt Splice Variant |
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Entrez Gene |
506235
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UniGene |
Bt.61991
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RefSeq |
NP_001070277
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AJ318490
AJ518959
AJ518960
AJ518961
BC123711
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GenPept |
AAI23712
CAC86392
CAD58796
CAD58797
CAD58798
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