InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HSF1

Summary

InnateDB Gene

IDBG-643592.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSF1

Gene Name

Heat shock factor protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020751

Encoded Proteins

IDBP-696154

Heat shock factor protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20018623

[Homo sapiens] HSF1 activated by heat shock induces the expression of ATF3, a negative regulator of IL-6, and ATF3 is necessary for heat-mediated suppression of IL-6, indicating a fever-mediated feedback loop consisting of HSF1 and ATF3.

PMID 22042134

[Homo sapiens] HSF1 is necessary to initiate host defence against Mycoplasma pneumoniae infection in the lungs through TLR2 signalling activation. (Demonstrated in mice)

PMID 22042134

[Mus musculus] Hsf1 is necessary to initiate host defence against Mycoplasma pneumoniae infection in the lungs through Tlr2 signalling activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185122:
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:1806081-1825793

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027654

ENSBTAP00000027654

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007143	female meiotic division
GO:0007283	spermatogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0032496	response to lipopolysaccharide
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034605	cellular response to heat
GO:0040018	positive regulation of multicellular organism growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060136	embryonic process involved in female pregnancy
GO:0090231	regulation of spindle checkpoint