Version 5.4
Bos taurus Protein: POLR2G
Summary
InnateDB Protein IDBP-696244.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2G
Protein Name DNA-directed RNA polymerase II subunit RPB7
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012481
InnateDB Gene IDBG-643671 (POLR2G)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0031369 translation initiation factor binding
Biological Process
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0045948 positive regulation of translational initiation
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR003029 Ribosomal protein S1, RNA-binding domain
IPR005576 RNA polymerase Rpb7, N-terminal
IPR012340 Nucleic acid-binding, OB-fold
IPR013238 RNA polymerase III, subunit Rpc25
IPR022967 RNA-binding domain, S1
PFAM PF00575
PF03876
PF08292
PRINTS
PIRSF
SMART SM00316
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9B8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 526320
UniGene
RefSeq NP_001015633
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT021002
GenPept AAX09019

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca