InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.88138

Summary

InnateDB Protein

IDBP-696298.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.88138

Protein Name

X-ray repair cross-complementing protein 5

Synonyms

XRCC5;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013758

InnateDB Gene

IDBG-643715 (BT.88138)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.

Predicted by orthology
Total	154 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0031625	ubiquitin protein ligase binding
GO:0042162	telomeric DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0008283	cell proliferation
GO:0032508	DNA duplex unwinding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050769	positive regulation of neurogenesis
GO:0060218	hematopoietic stem cell differentiation

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR005160 Ku70/Ku80 C-terminal arm
IPR005161 Ku70/Ku80, N-terminal alpha/beta
IPR006164 Ku70/Ku80 beta-barrel domain
IPR014893 Ku, C-terminal
IPR016194 SPOC like C-terminal domain

PFAM

PF00092
PF03730
PF03731
PF02735
PF08785

PRINTS

PIRSF

SMART

SM00327
SM00559

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite