Bos taurus Gene: BT.88138 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-643715.3 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | BT.88138 | ||||||||||||||||||||||||||
Gene Name | X-ray repair cross-complementing protein 5 | ||||||||||||||||||||||||||
Synonyms | XRCC5 | ||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000010426 | ||||||||||||||||||||||||||
Encoded Proteins |
X-ray repair cross-complementing protein 5
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts
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Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079246:
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 2:104656259-104744436 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
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REACTOME |
STING mediated induction of host immune responses pathway
2-LTR circle formation pathway
Integration of provirus pathway
Early Phase of HIV Life Cycle pathway
Processing of DNA ends prior to end rejoining pathway
Nonhomologous End-joining (NHEJ) pathway
IRF3-mediated induction of type I IFN pathway
Innate Immune System pathway
Double-Strand Break Repair pathway
Immune System pathway
HIV Life Cycle pathway
HIV Infection pathway
Cytosolic sensors of pathogen-associated DNA pathway
Disease pathway
DNA Repair pathway
Innate Immune System pathway
Double-Strand Break Repair pathway
Immune System pathway
Nonhomologous End-joining (NHEJ) pathway
DNA Repair pathway
IRF3-mediated induction of type I IFN pathway
Cytosolic sensors of pathogen-associated DNA pathway
STING mediated induction of host immune responses pathway
Processing of DNA ends prior to end rejoining pathway
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KEGG |
Non-homologous end-joining pathway
Non-homologous end-joining pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
Coregulation of Androgen receptor activity
BARD1 signaling events
DNA-PK pathway in nonhomologous end joining
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | G5E5D1 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 531945 | ||||||||||||||||||||||||||
UniGene | Bt.88138 | ||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||
HUGO | HGNC:12833 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | DAAA02005881 DAAA02005882 DAAA02005883 DAAA02005884 | ||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | 531945 | ||||||||||||||||||||||||||