Version 5.4
Bos taurus Protein: ARPC2
Summary
InnateDB Protein IDBP-696371.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC2
Protein Name Actin-related protein 2/3 complex subunit 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013707
InnateDB Gene IDBG-643785 (ARPC2)
Protein Structure
UniProt Annotation
Function Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007188 ARP2/3 complex, 34kDa subunit (p34-Arc)
PFAM PF04045
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHR7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540838
UniGene Bt.89426
RefSeq NP_001029885
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105136
GenPept AAI05137

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca