InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARPC2

Summary

InnateDB Gene

IDBG-643785.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARPC2

Gene Name

Actin-related protein 2/3 complex subunit 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010386

Encoded Proteins

IDBP-696371

Actin-related protein 2/3 complex subunit 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163466:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:106978526-107006143

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013707

ENSBTAP00000013707

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0010592	positive regulation of lamellipodium assembly
GO:0030833	regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0031252	cell leading edge
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome