InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AQP4

Summary

InnateDB Protein

IDBP-696393.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP4

Protein Name

Aquaporin-4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025341

InnateDB Gene

IDBG-643803 (AQP4)

Protein Structure

UniProt Annotation

Function

Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015250	water channel activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0007605	sensory perception of sound
GO:0030104	water homeostasis
GO:0050891	multicellular organismal water homeostasis
GO:0070295	renal water absorption
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like

PFAM

PF00230

PRINTS

PR00783

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O77750

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281008

UniGene

Bt.85960

RefSeq

NP_851346

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB012950 AB015947 AB028642 BC118415

GenPept

AAI18416 BAA33583 BAA36505 BAA89291