Version 5.4
Bos taurus Protein: VIL1
Summary
InnateDB Protein IDBP-696420.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VIL1
Protein Name villin-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024683
InnateDB Gene IDBG-643826 (VIL1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0035727 lysophosphatidic acid binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0051015 actin filament binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0009617 response to bacterium
GO:0010634 positive regulation of epithelial cell migration
GO:0030041 actin filament polymerization
GO:0030042 actin filament depolymerization
GO:0030335 positive regulation of cell migration
GO:0030855 epithelial cell differentiation
GO:0032233 positive regulation of actin filament bundle assembly
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051014 actin filament severing
GO:0051125 regulation of actin nucleation
GO:0051693 actin filament capping
GO:0060327 cytoplasmic actin-based contraction involved in cell motility
GO:0061041 regulation of wound healing
GO:0071364 cellular response to epidermal growth factor stimulus
GO:2000392 regulation of lamellipodium morphogenesis
Cellular Component
GO:0001726 ruffle
GO:0005902 microvillus
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0032432 actin filament bundle
GO:0032433 filopodium tip
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003128 Villin headpiece
IPR007122 Villin/Gelsolin
IPR007123 Gelsolin-like domain
PFAM PF02209
PF00626
PRINTS PR00597
PIRSF
SMART SM00153
SM00262
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5E9Z3
UniProt Splice Variant
Entrez Gene 281573
UniGene Bt.24710
RefSeq NP_001013609
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT020776 DAAA02005931
GenPept AAX08793

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca