InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VIL1

Summary

InnateDB Gene

IDBG-643826.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIL1

Gene Name

villin-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018543

Encoded Proteins

IDBP-696420

villin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127831:
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:107145491-107169192

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024683

ENSBTAP00000024683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0035727	lysophosphatidic acid binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0051015	actin filament binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008360	regulation of cell shape
GO:0009617	response to bacterium
GO:0010634	positive regulation of epithelial cell migration
GO:0030041	actin filament polymerization
GO:0030042	actin filament depolymerization
GO:0030335	positive regulation of cell migration
GO:0030855	epithelial cell differentiation
GO:0032233	positive regulation of actin filament bundle assembly
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051014	actin filament severing
GO:0051125	regulation of actin nucleation
GO:0051693	actin filament capping
GO:0060327	cytoplasmic actin-based contraction involved in cell motility
GO:0061041	regulation of wound healing
GO:0071364	cellular response to epidermal growth factor stimulus
GO:2000392	regulation of lamellipodium morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005902	microvillus
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0032432	actin filament bundle
GO:0032433	filopodium tip
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000127831

View Gene Order

ENSMUSG00000026175

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_14

IL2 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.24710

RefSeq

NM_001013591

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas