Version 5.4
Bos taurus Protein: VAV1
Summary
InnateDB Protein IDBP-696500.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAV1
Protein Name vav 1 guanine nucleotide exchange factor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005560
InnateDB Gene IDBG-643888 (VAV1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.
Predicted by orthology
Total 87 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0006909 phagocytosis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0030593 neutrophil chemotaxis
GO:0032314 regulation of Rac GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042110 T cell activation
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045785 positive regulation of cell adhesion
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005911 cell-cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00017
PF14633
PF00018
PF14604
PF00307
PF00169
PF07653
PRINTS PR00401
PR00452
PIRSF
SMART SM00325
SM00252
SM00326
SM00033
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MSK3
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:12657
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019536 DAAA02019537 DAAA02019538 DAAA02019539 DAAA02019540 DAAA02019541 DAAA02019542 DAAA02019543 DAAA02019544
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca