InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPHK1

Summary

InnateDB Protein

IDBP-69652.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPHK1

Protein Name

sphingosine kinase 1

Synonyms

SPHK;

Species

Homo sapiens

Ensembl Protein

ENSP00000313681

InnateDB Gene

IDBG-69650 (SPHK1)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269PubMed:20577214, ECO:0000269PubMed:23602659}.

Subcellular Localization

Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. {ECO:0000269PubMed:10802064}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008481	sphinganine kinase activity
GO:0017050	D-erythro-sphingosine kinase activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0001568	blood vessel development
GO:0001934	positive regulation of protein phosphorylation
GO:0001956	positive regulation of neurotransmitter secretion
GO:0006457	protein folding
GO:0006665	sphingolipid metabolic process
GO:0006670	sphingosine metabolic process
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420	brain development
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0009267	cellular response to starvation
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976	positive regulation of neuron projection development
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0016310	phosphorylation
GO:0019371	cyclooxygenase pathway
GO:0019722	calcium-mediated signaling
GO:0030148	sphingolipid biosynthetic process
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0031398	positive regulation of protein ubiquitination
GO:0032026	response to magnesium ion
GO:0032570	response to progesterone
GO:0032651	regulation of interleukin-1 beta production
GO:0033198	response to ATP
GO:0035556	intracellular signal transduction
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045931	positive regulation of mitotic cell cycle
GO:0045987	positive regulation of smooth muscle contraction
GO:0046521	sphingoid catabolic process
GO:0046834	lipid phosphorylation
GO:0048146	positive regulation of fibroblast proliferation
GO:0051084	'de novo' posttranslational protein folding
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070301	cellular response to hydrogen peroxide
GO:0070555	response to interleukin-1
GO:0071363	cellular response to growth factor stimulus