Version 5.4
Homo sapiens Gene: SPHK1
Summary
InnateDB Gene IDBG-69650.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPHK1
Gene Name sphingosine kinase 1
Synonyms SPHK
Species Homo sapiens
Ensembl Gene ENSG00000176170
Encoded Proteins
IDBP-69652
sphingosine kinase 1
IDBP-245545
sphingosine kinase 1
IDBP-600052
sphingosine kinase 1
IDBP-761909
IDBP-763471
IDBP-760096
IDBP-762872
IDBP-759282
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20634980
SPHK1 is involved in toll-mediated human beta-defensin 2 (HBD-2) regulation in oral keratinocytes, which also involves the activation of PI3K, AKT, GSK3B (GSK-3beta) and ERK 1/2.
PMID 20661259
SPHK1 activation, mediated by TLR4, is found to be critical for the redox-dependent activation of HIF-1alpha and ASK1, as well as for the prevention of LPS-induced activation of caspase 3 and the expression of pro-inflammatory cytokine interleukin-6.
PMID 26113114
(S)-methyl 2-(hexanamide)-3-(4-hydroxyphenyl) propanoate (MHP) activates SPHK1, which also stimulates CAMP production and enhances epidermal antimicrobial defence.
Entrez Gene
Summary The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:76376584-76387860
Strand Forward strand
Band q25.1
Transcripts
ENST00000323374 ENSP00000313681
ENST00000392496 ENSP00000376285
ENST00000545180 ENSP00000440970
ENST00000588682 ENSP00000466422
ENST00000592299 ENSP00000465726
ENST00000590379 ENSP00000465002
ENST00000590959 ENSP00000468547
ENST00000587167
ENST00000591762
ENST00000591651 ENSP00000468474
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008481 sphinganine kinase activity
GO:0017050 D-erythro-sphingosine kinase activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0001568 blood vessel development
GO:0001934 positive regulation of protein phosphorylation
GO:0001956 positive regulation of neurotransmitter secretion
GO:0006457 protein folding
GO:0006665 sphingolipid metabolic process
GO:0006670 sphingosine metabolic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007420 brain development
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell proliferation
GO:0009267 cellular response to starvation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976 positive regulation of neuron projection development
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0016310 phosphorylation
GO:0019371 cyclooxygenase pathway
GO:0019722 calcium-mediated signaling
GO:0030148 sphingolipid biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031398 positive regulation of protein ubiquitination
GO:0032026 response to magnesium ion
GO:0032570 response to progesterone
GO:0032651 regulation of interleukin-1 beta production
GO:0033198 response to ATP
GO:0035556 intracellular signal transduction
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045931 positive regulation of mitotic cell cycle
GO:0045987 positive regulation of smooth muscle contraction
GO:0046521 sphingoid catabolic process
GO:0046834 lipid phosphorylation
GO:0048146 positive regulation of fibroblast proliferation
GO:0051084 'de novo' posttranslational protein folding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070301 cellular response to hydrogen peroxide
GO:0070555 response to interleukin-1
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0030424 axon
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061878
View Gene Order
ENSBTAG00000008507
Not yet available
Pathways
NETPATH
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_111217
Metabolism pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa00600
Sphingolipid metabolism pathway
hsa04020
Calcium signaling pathway pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
s1p_s1p1_pathway
S1P1 pathway
integrin3_pathway
Beta3 integrin cell surface interactions
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt Q9NYA1
TrEMBL K7EJ32 K7EMA4 Q53ZR5 Q9BTG7
UniProt Splice Variant
Entrez Gene 8877
UniGene Hs.68061 Hs.739362
RefSeq NM_001142601 NM_001142602 NM_021972 NM_182965
HUGO HGNC:11240
OMIM 603730
CCDS CCDS45785 CCDS11744 CCDS59297
HPRD 04768
IMGT
EMBL AC090699 AF200328 AF238083 AF266756 AJ245504 AK022402 AK023393 AK292294 AK292614 AY278521 AY278522 AY278523 AY278524 AY278525 BC004112 BC009419 BC014439 BC030553 CH471099
GenPept AAF73423 AAF73470 AAG01980 AAH04112 AAH09419 AAH14439 AAH30553 AAP35060 BAB14028 BAB14558 BAF84983 BAF85303 CAB92131 EAW89388 EAW89389 EAW89390 EAW89391 EAW89392 EAW89393 EAW89394
RNA Seq Atlas 8877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca