Version 5.4
Bos taurus Protein: PTPRN
Summary
InnateDB Protein IDBP-696599.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRN
Protein Name Receptor-type tyrosine-protein phosphatase-like N
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018336
InnateDB Gene IDBG-643992 (PTPRN)
Protein Structure
UniProt Annotation
Function Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Lacks intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0030507 spectrin binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF11548
PRINTS PR00700
PIRSF
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56722
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 286810
UniGene Bt.61105
RefSeq NP_001068599
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF075170 BC119839
GenPept AAD41665 AAI19840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca