Version 5.4
Bos taurus Gene: PTPRN
Summary
InnateDB Gene IDBG-643992.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRN
Gene Name Receptor-type tyrosine-protein phosphatase-like N
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013798
Encoded Proteins
IDBP-696599
Receptor-type tyrosine-protein phosphatase-like N
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054356:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:107958895-107978251
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018336 ENSBTAP00000018336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0030507 spectrin binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000054356
View Gene Order
ENSMUSG00000026204
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04940
Type I diabetes mellitus pathway
mmu04940
Type I diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt P56722
TrEMBL
UniProt Splice Variant
Entrez Gene 286810
UniGene Bt.61105
RefSeq NM_001075131
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF075170 BC119839
GenPept AAD41665 AAI19840
RNA Seq Atlas 286810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca