InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ROCK1

Summary

InnateDB Protein

IDBP-696690.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROCK1

Protein Name

Rho-associated, coiled-coil containing protein kinase 1

Synonyms

p160ROCK; ROCK-I;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053818

InnateDB Gene

IDBG-644080 (ROCK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0003383	apical constriction
GO:0006468	protein phosphorylation
GO:0007159	leukocyte cell-cell adhesion
GO:0007165	signal transduction
GO:0016310	phosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0022614	membrane to membrane docking
GO:0030036	actin cytoskeleton organization
GO:0032060	bleb assembly
GO:0032970	regulation of actin filament-based process
GO:0035556	intracellular signal transduction
GO:0043524	negative regulation of neuron apoptotic process
GO:0045616	regulation of keratinocyte differentiation
GO:0050900	leukocyte migration
GO:0050901	leukocyte tethering or rolling
GO:0051451	myoblast migration
GO:0051894	positive regulation of focal adhesion assembly

Cellular Component

GO:0001726	ruffle
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011072 HR1 rho-binding repeat
IPR015008 Rho binding domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM