Version 5.4
Bos taurus Protein: INHA
Summary
InnateDB Protein IDBP-696691.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INHA
Protein Name Inhibin alpha chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013154
InnateDB Gene IDBG-644083 (INHA)
Protein Structure
UniProt Annotation
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0042127 regulation of cell proliferation
GO:0042541 hemoglobin biosynthetic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005576 extracellular region
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0043512 inhibin A complex
Protein Structure and Domains
PDB ID
InterPro IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR017175 Inhibin, alpha subunit subgroup
IPR029034 Cystine-knot cytokine
PFAM PF00019
PRINTS PR00669
PIRSF PIRSF037328
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07994
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281254
UniGene Bt.36723
RefSeq NP_776519
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109837 M13273 U16237
GenPept AAA97414 AAB60262 AAI09838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca