Version 5.4
Bos taurus Protein: COLEC12
Summary
InnateDB Protein IDBP-696738.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COLEC12
Protein Name Collectin-12
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000044662
InnateDB Gene IDBG-644123 (COLEC12)
Protein Structure
UniProt Annotation
Function Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Forms clusters on the cell surface. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008329 signaling pattern recognition receptor activity
GO:0030169 low-density lipoprotein particle binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006910 phagocytosis, recognition
GO:0006955 immune response
Cellular Component
GO:0005581 collagen trimer
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR008160 Collagen triple helix repeat
IPR016187 C-type lectin fold
PFAM PF00059
PF01391
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QP79
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504741
UniGene Bt.4492
RefSeq NP_001095313
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149193
GenPept AAI49194

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca