Version 5.4
Bos taurus Gene: COLEC12
Summary
InnateDB Gene IDBG-644123.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COLEC12
Gene Name Collectin-12
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007705
Encoded Proteins
IDBP-696738
Collectin-12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26290605
[Homo sapiens] Soluble COLEC12 can recognize Aspergillus fumigatus leading to activation of the alternative pathway of complement.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158270:
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:35630929-35816269
Strand Reverse strand
Band
Transcripts
ENSBTAT00000047455 ENSBTAP00000044662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008329 signaling pattern recognition receptor activity
GO:0030169 low-density lipoprotein particle binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0006910 phagocytosis, recognition
GO:0006955 immune response
Cellular Component
GO:0005581 collagen trimer
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158270
View Gene Order
ENSMUSG00000036103
View Gene Order
Pathways
NETPATH
REACTOME
REACT_209041
Scavenging by Class A Receptors pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_196581
Scavenging by Class A Receptors pathway
KEGG
hsa04145
Phagosome pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt A6QP79
TrEMBL
UniProt Splice Variant
Entrez Gene 504741
UniGene Bt.4492
RefSeq NM_001101843
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149193
GenPept AAI49194
RNA Seq Atlas 504741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca