Version 5.4
Bos taurus Protein: CAPN1
Summary
InnateDB Protein IDBP-696773.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN1
Protein Name Calpain-1 catalytic subunit
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011678
InnateDB Gene IDBG-644153 (CAPN1)
Protein Structure
UniProt Annotation
Function Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0032801 receptor catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
IPR002048 EF-hand domain
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family
PFAM PF00648
PF00036
PF13202
PF13405
PF01067
PRINTS PR00704
PIRSF
SMART SM00230
SM00054
SM00720
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q27970
PhosphoSite PhosphoSite-
TrEMBL Q6QDU0
UniProt Splice Variant
Entrez Gene 281661
UniGene Bt.252
RefSeq NP_776684
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF221129 AF248054 AF252504 AY545818 AY545820 AY545821 BC123635 EU386168 EU386169 EU386171 EU386173 EU386175 EU386176 EU386177 EU386180 EU386181 EU386182 EU386183 U07849
GenPept AAA18454 AAF32364 AAF64504 AAI23636 AAS66956 AAS66957 AAS66958 ACC95981 ACC95982 ACC95984 ACC95986 ACC95988 ACC95989 ACC95990 ACC95993 ACC95994 ACC95995 ACC95996

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca