InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CAPN1

Summary

InnateDB Gene

IDBG-644153.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN1

Gene Name

Calpain-1 catalytic subunit

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010230

Encoded Proteins

IDBP-696773

Calpain-1 catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000014216:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:44064429-44089990

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011678

ENSBTAP00000011678

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0032801	receptor catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000014216

View Gene Order

ENSMUSG00000024942

View Gene Order

Pathways

NETPATH

REACTOME

REACT_223425

Extracellular matrix organization pathway

REACT_201925

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_21

RANKL pathway

REACTOME

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_206066

Extracellular matrix organization pathway

REACT_199052

Degradation of the extracellular matrix pathway

KEGG

hsa04210

Apoptosis pathway

hsa05010

Alzheimer's disease pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

mmu05010

Alzheimer's disease pathway

mmu04210

Apoptosis pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

ptp1bpathway

Signaling events mediated by PTP1B

Cross-References

SwissProt

Q27970

TrEMBL

C6ERC1 Q6QDT7 Q6QDT8 Q6QDU0

UniProt Splice Variant

Entrez Gene

281661

UniGene

Bt.252

RefSeq

NM_174259

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF221129 AF248054 AF252504 AY545818 AY545820 AY545821 BC123635 EU386168 EU386169 EU386171 EU386173 EU386175 EU386176 EU386177 EU386180 EU386181 EU386182 EU386183 U07849

GenPept

AAA18454 AAF32364 AAF64504 AAI23636 AAS66956 AAS66957 AAS66958 ACC95981 ACC95982 ACC95984 ACC95986 ACC95988 ACC95989 ACC95990 ACC95993 ACC95994 ACC95995 ACC95996

RNA Seq Atlas

281661