InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1RAP

Summary

InnateDB Protein

IDBP-69684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RAP

Protein Name

interleukin 1 receptor accessory protein

Synonyms

C3orf13; IL-1RAcP; IL1R3;

Species

Homo sapiens

Ensembl Protein

ENSP00000072516

InnateDB Gene

IDBG-69682 (IL1RAP)

Protein Structure

UniProt Annotation

Function

Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269PubMed:10799889, ECO:0000269PubMed:12530978, ECO:0000269PubMed:9371760}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.

Disease Associations

Tissue Specificity

Detected in liver, skin, placenta, thymus and lung. {ECO:0000269PubMed:12530978}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR007110 Immunoglobulin-like domain

PFAM

PF01582
PF13676

PRINTS

PR01536

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt